I think I like MDX more, but it's 6" wider and longer, bad for a tight parking space at my office garage. I own a '99 RX 300 with 110k miles on it, so I trust Lexus. My wife wants smooth and quiet ride, and Lexus has the edge there. Any advise?

The Lexus RX350 is a lot better than the Acura MDX.

I would go with your wife, mdx seems to have transmission issue vs lexus damn good cars